Move the x360ce executable to a user-writable folder.
Alex didn't give up. Following advice from forums like Reddit and GitHub , they followed these steps to get back into the game: self protection failed error code 4 x360ce 2021
: After fixing, you can re-enable antivirus and Memory integrity – but you may need to repeat the admin run each time you use x360ce. Move the x360ce executable to a user-writable folder