If you are on a modern Mac and the device is not recognized, the most reliable "driverless" fix is to bypass the Radium’s internal USB interface entirely.
: For older macOS versions (10.10 and below), users have successfully used the MIDI USB Driver v3.5.3 Audio MIDI Setup Utility m-audio radium 49 driver mac
By manually setting these to standard numbers, you can often "trick" your DAW into recognizing them even without the official driver, using the DAW's "MIDI Learn" function (usually Command + L in Logic Pro, or the wrench icon in Ableton Live). If you are on a modern Mac and
The M-Audio Radium 49 is an "end of life" legacy product that is on modern macOS versions . Unlike newer M-Audio controllers, the Radium 49 is not class-compliant , meaning it requires specific software drivers to function over a direct USB connection. Official Support Status Unlike newer M-Audio controllers, the Radium 49 is
The official M-Audio Radium 49 drivers released in the mid-2000s were . Apple began phasing out 32-bit support in macOS Catalina (10.15) and eliminated it entirely. No 32-bit driver or software will run on macOS Catalina, Big Sur, Monterey, Ventura, Sonoma, or Sequoia.