You are tasked with synthesizing 2-allyl-2-methylcyclohexanone. Starting from 2-methylcyclohexanone, describe the specific conditions required to achieve alkylation at the more substituted carbon. Key Concept: Kinetic vs. Thermodynamic Enolates. The Parameters: Base selection (LDA vs. cap K cap H cap E t sub 3 cap N Temperature (–78°C vs. Room Temp). Solvent effects. The Solution Hint: To hit the more substituted carbon, you need the thermodynamic enolate
Key concepts
Regenerating the Pd(0) catalyst and forming the C-C bond. 4. Stereoselective and Asymmetric Synthesis advanced organic chemistry practice problems