Not all save files are created equal. There are two major versions of RE4 on PC:
Right-click savedata.dat > Properties. Ensure "Read-only" is unchecked . The game cannot write a check-sum to a read-only file. save game resident evil 4 pc exclusive
Right-click the game in Steam > Properties > General > Toggle off Steam Cloud. Not all save files are created equal
Unlike modern JSON or XML save files, the 2007 RE4 uses a proprietary, encrypted .dat file. This file contains all three save slots (Slot 1, Slot 2, Slot 3) in one binary block. the 2007 RE4 uses a proprietary
Would you like a guide on how to edit your savedata.bin or install a save‑anywhere mod?