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Pain activates the brain’s insula and anterior cingulate cortex—regions associated with both physical and emotional distress. But chronic pain sufferers who practice mindfulness or acceptance-based therapies show increased gray matter in the prefrontal cortex, linked to emotional regulation.

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Yet the world’s greatest art, literature, philosophy, and religious traditions all point to a startling paradox: Not because suffering is good, but because our response to it reveals who we truly are. Pain activates the brain’s insula and anterior cingulate

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