These versions are often patched to boot directly from a hard drive (HDD) or USB via Open PS2 Loader (OPL) without needing the physical disc.
Are you running into a specific error when launching games? codebreaker ps2 v101 iso updated
Have a favorite cheat code for a hidden gem? Share it in the comments below (or on the r/PS2 subreddit). And remember: always dump your own BIOS and game discs. These versions are often patched to boot directly