Playing the FIFA 16 PS2 ISO on PCSX2 is smooth even on modest hardware. Here are recommended settings:
The PS2 hardware limitations do mean that some features, such as online play, are not available. However, for those looking for a single-player experience or local multiplayer action, FIFA 16 PS2 ISO more than delivers.
FIFA 16 is a soccer simulation video game developed by EA Canada and published by Electronic Arts (EA). Released in 2015, it was the 24th edition of the FIFA series. The game introduced several new features, including the "Women's National Teams" mode, which allowed players to control female national teams for the first time in the series' history.
To play this ISO, you generally need either a modded PS2 console or the for PC.
Here is a blog post exploring the reality and the "myth" of FIFA 16 on the PS2.