His debut as a lead actor. A soulful village drama that won National Awards and showcased his ability to handle emotional depth.

Post-pandemic, Sethupathi experimented heavily with direct-to-digital releases and diverse genres.

A horror-thriller that established him as a leading actor in Tamil cinema.

Established him as a versatile performer with a "natural" style. Naanum Rowdy Dhaan , Sethupathi , Dharma Durai , Vikram Vedha Vikram Vedha is widely considered one of his best works. Critical Acclaim (2018–2021) , Super Deluxe , ,

| Year | Movie Title | Role | Notes | |------|-------------|------|-------| | 2010 | Thenmerku Paruvakaatru | Murugan | Debut film | | 2010 | Naan Mahan Alla | K. Selvam | Supporting role | | 2012 | Sundarapandian | Sundarapandian | First lead role | | 2012 | Pizza | Michael | Breakthrough hit | | 2012 | Naduvula Konjam Pakkatha Kaanom | Sampath | Cult classic | | 2013 | Soodhu Kavvum | Das | Black comedy hit | | 2013 | Idharkuthane Aasaipattai Balakumara | Kumaran | Comedy role | | 2013 | Rummy | Sakthi | Romantic drama | | 2013 | Pannaiyarum Padminiyum | Murugan | Critically acclaimed |